New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
- Horikoshi, M.
- Yaghootkar, H.
- Mook-Kanamori, D.O.
- Sovio, U.
- Taal, H.R.
- Hennig, B.J.
- Bradfield, J.P.
- St Pourcain, B.
- Evans, D.M.
- Charoen, P.
- Kaakinen, M.
- Cousminer, D.L.
- Lehtimäki, T.
- Kreiner-Møller, E.
- Warrington, N.M.
- Bustamante, M.
- Feenstra, B.
- Berry, D.J.
- Thiering, E.
- Pfab, T.
- Barton, S.J.
- Shields, B.M.
- Kerkhof, M.
- van Leeuwen, E.M.
- Fulford, A.J.
- Kutalik, Z.
- Zhao, J.H.
- den Hoed, M.
- Mahajan, A.
- Lindi, V.
- Goh, L.K.
- Hottenga, J.J.
- Wu, Y.
- Raitakari, O.T.
- Harder, M.N.
- Meirhaeghe, A.
- Ntalla, I.
- Salem, R.M.
- Jameson, K.A.
- Zhou, K.
- Monies, D.M.
- Lagou, V.
- Kirin, M.
- Heikkinen, J.
- Adair, L.S.
- Alkuraya, F.S.
- Al-Odaib, A.
- Amouyel, P.
- Andersson, E.A.
- Bennett, A.J.
- Blakemore, A.I.
- Buxton, J.L.
- Dallongeville, J.
- Das, S.
- de Geus, E.J.
- Estivill, X.
- Flexeder, C.
- Froguel, P.
- Geller, F.
- Godfrey, K.M.
- Gottrand, F.
- Groves, C.J.
- Hansen, T.
- Hirschhorn, J.N.
- Hofman, A.
- Hollegaard, M.V.
- Hougaard, D.M.
- Hyppönen, E.
- Inskip, H.M.
- Isaacs, A.
- Jørgensen, T.
- Kanaka-Gantenbein, C.
- Kemp, J.P.
- Kiess, W.
- Kilpeläinen, T.O.
- Klopp, N.
- Knight, B.A.
- Kuzawa, C.W.
- McMahon, G.
- Newnham, J.P.
- Niinikoski, H.
- Oostra, B.A.
- Pedersen, L.
- Postma, D.S.
- Ring, S.M.
- Rivadeneira, F.
- Robertson, N.R.
- Sebert, S.
- Simell, O.
- Slowinski, T.
- Tiesler, C.M.
- Tönjes, A.
- Vaag, A.
- Viikari, J.S.
- Vink, J.M.
- Vissing, N.H.
- Wareham, N.J.
- Willemsen, G.
- Witte, D.R.
- Zhang, H.
- Zhao, J.
- Meta-Analyses of, Glucose-
- Wilson, J.F.
- Wilson, J.F.
- Stumvoll, M.
- Prentice, A.M.
- Meyer, B.F.
- Pearson, E.R.
- Boreham, C.A.
- Cooper, C.
- Gillman, M.W.
- Dedoussis, G.V.
- Moreno, L.A.
- Pedersen, O.
- Saarinen, M.
- Mohlke, K.L.
- Boomsma, D.I.
- Saw, S.M.
- Lakka, T.A.
- Körner, A.
- Loos, R.J.
- Ong, K.K.
- Vollenweider, P.
- van Duijn, C.M.
- Koppelman, G.H.
- Hattersley, A.T.
- Holloway, J.W.
- Hocher, B.
- Heinrich, J.
- Power, C.
- Melbye, M.
- Guxens, M.
- Pennell, C.E.
- Bønnelykke, K.
- Bisgaard, H.
- Eriksson, J.G.
- Widén, E.
- Hakonarson, H.
- Uitterlinden, A.G.
- Pouta, A.
- Lawlor, D.A.
- Smith, G.D.
- Frayling, T.M.
- McCarthy, M.I.
- Grant, S.F.
- Jaddoe, V.W.
- Jarvelin, M.R.
- Timpson, N.J.
- Prokopenko, I.
- Freathy, R.M.
DOIAbstract
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phen...
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