Development of a control banding tool for nanomaterials

Control banding (CB) can be a useful tool for managing the potential risks of nanomaterials. The here proposed CB, which should be part of an overall risk control strategy, groups materials by hazard and emission potential. The resulting decision matrix proposes control bands adapted to the risk potential levels and helps define an action plan. If this plan is not practical and financially feasible, a full risk assessment is launched. The hazard banding combines key concepts of nanomaterial toxicology: translocation across biological barriers, fibrous nature, solubility, and reactivity. Already existing classifications specific to the nanomaterial can be used "as is." Otherwise, the toxicity of bulk or analogous substances gives an initial hazard band, which is increased if the substance is not easily soluble or if it has a higher reactivity than the substance. The emission potential bands are defined by the nanomaterials' physical form and process characteristics. Quantities, frequencies, and existing control measures are taken into account during the definition of the action plan. Control strategies range from room ventilation to full containment with expert advice. This CB approach, once validated, can be easily embedded in risk management systems. It allows integrating new toxicity data and needs no exposure data. [Authors]]]> Nanoparticles ; Risk Assessment ; Occupational Exposure eng https://serval.unil.ch/resource/serval:BIB_89875793AD57.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89875793AD579 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_89875793AD579 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_89877752F262 2023-07-29T01:29:31Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_89877752F262 PROSPECT guideline for rotator cuff repair surgery: systematic review and procedure‐specific postoperative pain management recommendations info:doi:10.1111/anae.14796 info:eu-repo/semantics/altIdentifier/doi/10.1111/anae.14796 info:eu-repo/semantics/altIdentifier/pmid/31392721 Toma, O. Persoons, B. Pogatzki-Zahn, E. Van de Velde, M. Joshi, G. P. Schug, S Kehlet, H Bonnet, F Rawal, N Delbos, A Lavand'homme, P Beloeil, H Raeder, J Sauter, A Albrecht, E Lirk, P info:eu-repo/semantics/article article 2019-10 Anaesthesia, vol. 74, no. 10, pp. 1320-1331 info:eu-repo/semantics/altIdentifier/pissn/0003-2409 info:eu-repo/semantics/altIdentifier/pissn/1365-2044 Anesthesiolog, Pain Medicine, Postoperative Pain, Rotator cuff repair eng https://serval.unil.ch/resource/serval:BIB_89877752F262.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89877752F2629 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_89877752F2629 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess CC BY-NC 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf oai:serval.unil.ch:BIB_89880A60EA7B 2023-07-29T01:29:31Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_89880A60EA7B Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies. info:doi:10.1016/j.clnu.2020.05.012 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clnu.2020.05.012 info:eu-repo/semantics/altIdentifier/pmid/32534950 Redeuil, K. Lévêques, A. Oberson, J.M. Bénet, S. Tissot, E. Longet, K. de Castro, A. Romagny, C. Beauport, L. Fischer Fumeaux, C.J. Tolsa, J.F. Affolter, M. Giménez, E.C. Garcia-Rodenas, C.L. Thakkar, S.K. info:eu-repo/semantics/article article 2021-01 Clinical nutrition, vol. 40, no. 1, pp. 222-228 info:eu-repo/semantics/altIdentifier/eissn/1532-1983 urn:issn:0261-5614 <![CDATA[Differences in vitamin and carotenoids content of human milk (HM) produced for infants born at term and preterm is poorly understood. In this study, HM was collected weekly for four and two months post-partum for preterm and term groups, respectively. Nutrients of interest, from single full breast expressions were measured by liquid chromatography coupled with mass spectrometry. Microbiological assay was employed for vitamin B &lt;sub&gt;12&lt;/sub&gt; . When compared at equivalent post-partum age, vitamins B &lt;sub&gt;1&lt;/sub&gt; , B &lt;sub&gt;2&lt;/sub&gt; , B &lt;sub&gt;6&lt;/sub&gt; , and B &lt;sub&gt;9&lt;/sub&gt; were significantly higher in preterm than in term HM, but only during the first two weeks. No significant differences were observed for A, E, B &lt;sub&gt;3&lt;/sub&gt; and B &lt;sub&gt;12&lt;/sub&gt; between groups. Lycopene was the only carotenoid exhibiting a significant higher concentration in term than in preterm HM between weeks 1 and 4 post-partum. When compared at equivalent post-menstrual age, preterm milk was significantly higher for vitamins B &lt;sub&gt;1&lt;/sub&gt; , B &lt;sub&gt;2&lt;/sub&gt; , B &lt;sub&gt;3&lt;/sub&gt; , B &lt;sub&gt;6&lt;/sub&gt; and B &lt;sub&gt;9&lt;/sub&gt; and lower levels of vitamins A, E, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene compared to their term counterparts. These results suggest that preterm breastfed infants at term equivalent age may receive lower amounts of these micronutrients than breast-fed term neonates, possibly highlighting the need to supplement or fortify their nutritional intake with vitamins and carotenoids. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT #02052245