High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis.
- Miró, J.M.
- Entenza, J.M.
- Del Río, A.
- Velasco, M.
- Castañeda, X.
- Garcia de la Mària, C.
- Giddey, M.
- Armero, Y.
- Pericàs, J.M.
- Cervera, C.
- Mestres, C.A.
- Almela, M.
- Falces, C.
- Marco, F.
- Moreillon, P.
- Moreno, A.
DOIAbstract
We describe 3 patients with left-sided staphylococcal endocarditis (1 with methicillin-susceptible Staphylococcus aureus [MSSA] prosthetic aortic valve endocarditis and 2 with methicillin-resistant S. aureus [MRSA] native-valve endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks. This combination was tested in vitro against 7 MSSA, 5 MRSA, and 2 intermediately glycopeptide-resistant S. aureus isolates and proved to be synergistic against 11 (79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study
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