Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell ...
Cytosolic double stranded DNA (dsDNA) is sensed as a “danger signal” by host cells. Detection of vir...
AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukar...
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (al...
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1beta (IL-1beta) ...
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA...
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (al...
The innate immune system plays a key role in modulating host immune defense during bacterial disease...
Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous products release...
Recognition of pathogens and altered self must be efficient and highly specific to orchestrate appro...
The innate immune system recognizes nucleic acids during infection and tissue damage. Whereas viral ...
Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues contain...
Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues contain...
SummaryRecognition of DNA by the innate immune system is central to antiviral and antibacterial defe...
The innate immune system is the body’s first line of defense against danger, either from pathogens o...
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell ...
Cytosolic double stranded DNA (dsDNA) is sensed as a “danger signal” by host cells. Detection of vir...
AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukar...
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (al...
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1beta (IL-1beta) ...
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA...
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (al...
The innate immune system plays a key role in modulating host immune defense during bacterial disease...
Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous products release...
Recognition of pathogens and altered self must be efficient and highly specific to orchestrate appro...
The innate immune system recognizes nucleic acids during infection and tissue damage. Whereas viral ...
Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues contain...
Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues contain...
SummaryRecognition of DNA by the innate immune system is central to antiviral and antibacterial defe...
The innate immune system is the body’s first line of defense against danger, either from pathogens o...
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell ...
Cytosolic double stranded DNA (dsDNA) is sensed as a “danger signal” by host cells. Detection of vir...
AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukar...
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