E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle selective, and HCF-1 displays coactivator properties when bound to the E2F1 activator and corepressor properties when bou...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. ...
E2F transcriptional regulators control human-cell proliferation by repressing and activating the tra...
E2F1 is a key positive regulator of human cell proliferation and its activity is altered in essentia...
SummaryHost cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle...
The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repress...
The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repress...
E2F Transcription Factor 1 (E2F1) E2F1 is a transcription factor, in which its expression is increas...
SummaryHost cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 pr...
Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. ...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 pr...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. ...
E2F transcriptional regulators control human-cell proliferation by repressing and activating the tra...
E2F1 is a key positive regulator of human cell proliferation and its activity is altered in essentia...
SummaryHost cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle...
The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repress...
The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repress...
E2F Transcription Factor 1 (E2F1) E2F1 is a transcription factor, in which its expression is increas...
SummaryHost cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 pr...
Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. ...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 pr...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
The E2F family of transcription factors plays a central role in regulating cellular proliferation by...
Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. ...