Add to ORKGMethylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken β-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin
The relationship between chromatin modification and lymphocyte development is still poorly understoo...
SummaryHistone modifications are implicated in influencing gene expression. We have generated high-r...
Histones are DNA-associated proteins that contribute to chromatin structure and regulation. Modifica...
Methylation of histones at specific residues plays an important role in transcriptional regulation. ...
Post-translational modifications of individual lysine residues of core histones can exert unique fun...
The chicken embryonic β-type globin gene, ρ, is silenced on day five of embryogenesis. Concomitant w...
We have studied developmentally regulated patterns of histone acetylation at high resolution across ...
Using native chromatin immunoprecipitation (N-ChIP) followed by TaqMan RT-PCR quantitative analysis ...
AbstractWe have analysed the 5-methylcytosine content of hen erythrocyte DNA and found it to be lowe...
AbstractDNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become...
Objective<p></p> The regulation of the β-globin switch remains undetermined, and unders...
Funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.The production of...
Complex patterns of histone lysine methylation encode distinct functions within chromatin. We previo...
Individual differentiated somatic cells and undifferentiated stem cells have common genome, although...
We have identified a folate receptor gene upstream of the chicken β-globin locus and separated from ...
The relationship between chromatin modification and lymphocyte development is still poorly understoo...
SummaryHistone modifications are implicated in influencing gene expression. We have generated high-r...
Histones are DNA-associated proteins that contribute to chromatin structure and regulation. Modifica...
Methylation of histones at specific residues plays an important role in transcriptional regulation. ...
Post-translational modifications of individual lysine residues of core histones can exert unique fun...
The chicken embryonic β-type globin gene, ρ, is silenced on day five of embryogenesis. Concomitant w...
We have studied developmentally regulated patterns of histone acetylation at high resolution across ...
Using native chromatin immunoprecipitation (N-ChIP) followed by TaqMan RT-PCR quantitative analysis ...
AbstractWe have analysed the 5-methylcytosine content of hen erythrocyte DNA and found it to be lowe...
AbstractDNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become...
Objective<p></p> The regulation of the β-globin switch remains undetermined, and unders...
Funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.The production of...
Complex patterns of histone lysine methylation encode distinct functions within chromatin. We previo...
Individual differentiated somatic cells and undifferentiated stem cells have common genome, although...
We have identified a folate receptor gene upstream of the chicken β-globin locus and separated from ...
The relationship between chromatin modification and lymphocyte development is still poorly understoo...
SummaryHistone modifications are implicated in influencing gene expression. We have generated high-r...
Histones are DNA-associated proteins that contribute to chromatin structure and regulation. Modifica...