Add to ORKGThe present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the bacterial cell wall. The present invention is also directed to methods of making live-attenuated vaccines against pathogenic mycobacteria using such alrA mutants and to the vaccines made according to such methods. The present invention is further directed to use of alrA mutants in methods for screening antimycobacterial agents that are synergistic with peptidoglycan inhibitors. Finally, the present invention is directed to methods to identify new pathways of D-alanine biosynthesis for use in developing new drug...
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evoluti...
In mycobacteria, D-alanine is an essential precursor for peptidoglycan biosynthesis. The only confir...
The genus Mycobacterium includes several pathogens that cause severe disease in humans, like Mycobac...
Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic myc...
Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basi...
D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tubercu...
D-alanine is a structural component of mycobacterial peptidoglycan. The primary route of d-alanine b...
Tuberculosis is a disease that is one of the leading ten causes of death worldwide and is believed t...
Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), results in seriou...
Tauch A, Götker S, Pühler A, Kalinowski J, Thierbach G. The alanine racemase gene alr is an alternat...
D-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes D-alanine racemase (Alr) and Dala...
Copyright © 2017 Nakatani et al.A screening of more than 1,500 drug-resistant strains of Mycobacteri...
In the course of developing strategies to obtain a mutation in the aspartate semialdehyde dehydrogen...
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne’s Disease in rumin...
Mycobacterium tuberculosis is a serious health problem worldwide, and cannot be conquered without an...
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evoluti...
In mycobacteria, D-alanine is an essential precursor for peptidoglycan biosynthesis. The only confir...
The genus Mycobacterium includes several pathogens that cause severe disease in humans, like Mycobac...
Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic myc...
Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basi...
D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tubercu...
D-alanine is a structural component of mycobacterial peptidoglycan. The primary route of d-alanine b...
Tuberculosis is a disease that is one of the leading ten causes of death worldwide and is believed t...
Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), results in seriou...
Tauch A, Götker S, Pühler A, Kalinowski J, Thierbach G. The alanine racemase gene alr is an alternat...
D-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes D-alanine racemase (Alr) and Dala...
Copyright © 2017 Nakatani et al.A screening of more than 1,500 drug-resistant strains of Mycobacteri...
In the course of developing strategies to obtain a mutation in the aspartate semialdehyde dehydrogen...
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne’s Disease in rumin...
Mycobacterium tuberculosis is a serious health problem worldwide, and cannot be conquered without an...
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evoluti...
In mycobacteria, D-alanine is an essential precursor for peptidoglycan biosynthesis. The only confir...
The genus Mycobacterium includes several pathogens that cause severe disease in humans, like Mycobac...