Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript
- Perng, Guey-Chuen
- Jones, Clinton J.
- Ciacci-Zanella, Janice
- Stone, Melissa
- Henderson, Gail A.
- Yukht, Ada
- Slanina, Susan M.
- Hofman, Florence M.
- Ghiasi, Homayon
- Nesburn, Anthony B.
- Wechsler, Steven L.
Publication date
February 2000
DOI Publisher
DigitalCommons@University of Nebraska - Lincoln ISSN
0036-8075 Language
English Citation count (estimate)
337Abstract
Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis
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