This NebGuide discusses the causes, clinical signs, diagnosis, treatment, and prevention methods of this potentially fatal disease. Enterotoxemia, which is also known as overeating or pulpy kidney disease, is a highly significant and costly disease problem for the sheep industry. Proper preventive practices are strongly recommended to sheep producers in order to avoid death loss from this disease. The word enterotoxemia can be broken down into three parts that can be an aid in understanding the disease. The term entero refers to intestine; tox refers to toxin or poison; and emia refers to blood. Thus, from intestinal toxin in the blood comes the term enterotoxemia