A hallmark of cancer is genomic instability that is considered to provide the adaptive capacity of cancers to thrive under conditions in which the normal precursors would not survive. Recent genomic analysis has revealed a very high degree of genomic instability in melanomas, although the mechanism by which this instability arises is not known. Here we report that a high proportion (68%) of melanoma cell lines are either partially (40%) or severely (28%) compromised for the G(2) phase decatenation checkpoint that normally functions to ensure that the sister chromatids are able to separate correctly during mitosis. The consequence of this loss of checkpoint function is a severely reduced ability to partition the replicated genome in mitosis ...
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alter...
<div><p>To reveal the clonal architecture of melanoma and associated driver mutations, whole genome ...
Malignant melanoma is an aggressive, heterogeneous disease where new biomarkers for diagnosis and cl...
A hallmark of cancer is genomic instability that is considered to provide the adaptive capacity of c...
Melanoma cell lines are commonly defective for the G2-phase cell cycle checkpoint that responds to i...
Melanoma cell lines are commonly defective for the G2-phase cell cycle checkpoint that responds to i...
Melanomas have high levels of genomic instability that can contribute to poor disease prognosis. Her...
Defects in DNA damage responses may underlie genetic instability and malignant progression in melano...
Defects in DNA damage responses may underlie genetic instability and malignant progression in melano...
Chromosomal instability plays a pivotal role in multistep carcinogenesis by facilitating the acquisi...
One of the most common characteristics of cancer cells is genomic instability. Recent research has r...
Melanoma is a severe skin cancer affecting thousands of people and a growing public health concern w...
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melan...
The ultraviolet radiation (UVR) component of sunlight is the major environmental risk factor for mel...
One of the fundamental challenges facing the cell is to accurately copy its geneticmaterial to daugh...
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alter...
<div><p>To reveal the clonal architecture of melanoma and associated driver mutations, whole genome ...
Malignant melanoma is an aggressive, heterogeneous disease where new biomarkers for diagnosis and cl...
A hallmark of cancer is genomic instability that is considered to provide the adaptive capacity of c...
Melanoma cell lines are commonly defective for the G2-phase cell cycle checkpoint that responds to i...
Melanoma cell lines are commonly defective for the G2-phase cell cycle checkpoint that responds to i...
Melanomas have high levels of genomic instability that can contribute to poor disease prognosis. Her...
Defects in DNA damage responses may underlie genetic instability and malignant progression in melano...
Defects in DNA damage responses may underlie genetic instability and malignant progression in melano...
Chromosomal instability plays a pivotal role in multistep carcinogenesis by facilitating the acquisi...
One of the most common characteristics of cancer cells is genomic instability. Recent research has r...
Melanoma is a severe skin cancer affecting thousands of people and a growing public health concern w...
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melan...
The ultraviolet radiation (UVR) component of sunlight is the major environmental risk factor for mel...
One of the fundamental challenges facing the cell is to accurately copy its geneticmaterial to daugh...
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alter...
<div><p>To reveal the clonal architecture of melanoma and associated driver mutations, whole genome ...
Malignant melanoma is an aggressive, heterogeneous disease where new biomarkers for diagnosis and cl...