Sublingual immunotherapy not effective in house dust mite-allergic children in primary care

Background: Sublingual immunotherapy (SLIT) as a therapy for the treatment of allergic rhinitis in children might be acceptable as an alternative for subcutaneous immunotherapy. However, the efficacy of SLIT with house dust mite extract is not well established. Objective: To investigate whether SLIT in house dust miteallergic children recruited in primary care is effective and safe. Methods: Children aged 618 years (n = 251) recruited in primary care with a house dust miteinduced allergic rhinitis received either SLIT or placebo for 2 years. Symptoms and medication use were assessed throughout the study. Primary outcome parameter was the mean total nose symptom score (scales 012) during the autumn of the second treatment year. Safety was assessed by recording any adverse event. Results: Overall, the mean nose symptom score +/- s.d. after 2 years of treatment showed no significant effect of SLIT (symptom score intervention group 2.26 +/- 1.84 vs. placebo group, 2.02 +/- 1.67; p = 0.08). There were no significant differences in secondary outcomes, nor in subgroup analyses. The number of patients reporting adverse events was comparable between both groups. Conclusions: Sublingual immunotherapy with house dust mite allergen was not better than placebo in reducing rhinitis symptoms in house dust miteallergic children in primary care. SLIT as administered in this study can be considered safe