The properties of the Interstellar Medium (ISM) strongly influence the environment and processes that lead to star-formation, which in turn, drives the evolution of a galaxy. Dwarf galaxies in the Local Group are perfect laboratories to investigate how the metal-poor ISM affects the interplay between gas, dust and stars. In this thesis, I investigate the properties of the HII regions and the diffuse ionized gas of the nearby dwarf galaxy IC10, which has a metallicity of 1/3 solar. Its proximity (d=700 kpc) enables the analysis on different spatial scales: from the compact clumps (~25 pc) to the whole star-forming body of the galaxy (~650pc). In order to measure the physical properties of the ISM, I model the infrared emission lines observed...