International audienceThe enantioselective H-transfer hydrogenation of quinoline by Hantzsch ester is a relevant example of Brønsted acid catalyzed cascade reactions, with phosphoric acid being a privileged catalyst. The generally accepted mechanism points out the hydride transfer step as the rate- and stereodetermining step, however computations based on these models do not totally fit with experimental observations. We hereby present a computational study that enlightens the stereochemical outcome and quantitatively reproduces the experimental enantiomeric excesses in a series of H-transfer hydrogenations. Our calculations suggest that the high stereocontrol usually attained with BINOL-derived phosphoric acids results mostly from the ster...
Kinetic resolution is a widely used strategy for separation and enrichment of enantiomers. Using den...
International audienceA reinvestigation of a chiral phosphoric-acidcatalyzedfour-component Hantzsch ...
The mode of enantioselection in the proline modified asymmetric hydrogenation of isophorone (3,5,5-t...
International audienceThe enantioselective H-transfer hydrogenation of quinoline by Hantzsch ester i...
Chiral BINOL-derived phosphoric acids catalyse the transfer hydrogenation of ketimines using Hantszc...
Benzothiazoline is an efficient reducing agent for the chiral BINOL-phosphoric acid catalyzed enanti...
BINOL-derived phosphoric acids catalyze the asymmetric allylboration of aldehydes. DFT and QM/MM hyb...
BINOL-derived phosphoric acids catalyze the asymmetric allylboration of aldehydes. DFT and QM/MM hyb...
CONSPECTUS: Chiral phosphoric acids have become powerful catalysts for the stereocontrolled synthesi...
Chiral phosphoric acids are bifunctional catalysts that have the ability to activate electrophiles a...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
Choosing the optimal catalyst for a new transformation is challenging because the ideal molecular re...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
Chiral phosphoric acids (CPA) have become a privileged catalyst type in organocatalysis, but the sel...
Kinetic resolution is a widely used strategy for separation and enrichment of enantiomers. Using den...
International audienceA reinvestigation of a chiral phosphoric-acidcatalyzedfour-component Hantzsch ...
The mode of enantioselection in the proline modified asymmetric hydrogenation of isophorone (3,5,5-t...
International audienceThe enantioselective H-transfer hydrogenation of quinoline by Hantzsch ester i...
Chiral BINOL-derived phosphoric acids catalyse the transfer hydrogenation of ketimines using Hantszc...
Benzothiazoline is an efficient reducing agent for the chiral BINOL-phosphoric acid catalyzed enanti...
BINOL-derived phosphoric acids catalyze the asymmetric allylboration of aldehydes. DFT and QM/MM hyb...
BINOL-derived phosphoric acids catalyze the asymmetric allylboration of aldehydes. DFT and QM/MM hyb...
CONSPECTUS: Chiral phosphoric acids have become powerful catalysts for the stereocontrolled synthesi...
Chiral phosphoric acids are bifunctional catalysts that have the ability to activate electrophiles a...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
Choosing the optimal catalyst for a new transformation is challenging because the ideal molecular re...
We have studied the proline-directed, Pd-catalyzed enantioselective hydrogenation of isophorone in t...
Chiral phosphoric acids (CPA) have become a privileged catalyst type in organocatalysis, but the sel...
Kinetic resolution is a widely used strategy for separation and enrichment of enantiomers. Using den...
International audienceA reinvestigation of a chiral phosphoric-acidcatalyzedfour-component Hantzsch ...
The mode of enantioselection in the proline modified asymmetric hydrogenation of isophorone (3,5,5-t...