International audienceOrganic Rankine Cycle (ORC) turbines usually operate in thermodynamic regions characterized by high-pressure ratios and strong non-ideal gas effects in the flow expansion, complicating their aerodynamic design significantly. This study presents the shape optimization of a typical 2D ORC turbine cascade (Biere), under epistemic uncertainties due to turbulence models (RANS). A design vector of size eleven controls the blade geometry parametrized with B-splines. The EQUiPS module integrated into the SU2 CFD suite, incorporating perturbations to the eigenvalues and the eigenvectors of the modeled Reynolds stress tensor, is used to evaluate the interval estimates on the predictions of integrated Quantity of Interest (QoI), ...