International audienceThe archaeological site of Guado San Nicola (Monteroduni, Central Italy), under excavation since 2008, is located in the Upper Volturno Valley, near the top of a fluvial terrace attributed to the Middle Pleistocene. Several anthropic levels have been recognized within a stratigraphic sequence of more than two meters in thickness, characterized by alternating gravelly and sandy fluvial layers rich in pyroclastic materials, attributable to the end of MIS 11-beginning of MIS 10, according to the obtained radiometric dates (Ar-40/Ar-39 and ESR/U-series). In this paper we discuss the chrono-stratigraphic record, the paleontological and zooarchaeological data and we provide a detailed techno-economic analysis of the lithic i...