International audienceThe middle atmosphere (from about 10–110 km altitude) is a highly variable environment at seasonal and sub-seasonal timescales. This variability influences the general atmospheric circulation through the propagation and breaking of planetary and gravity waves. Multi-instrument observations, performed in the framework of the ARISE (Atmospheric Dynamics Research InfraStructure in Europe) project, are used to quantify uncertainties in Numerical Weather Prediction (NWP) models such as the one of the European Centre for Medium-Range Weather Forecasts (ECMWF). We show the potential of routine and measurement campaigns to monitor the evolution of the middle atmosphere and demonstrate the limitations of NWP models to properly ...