Thyroidal effects of di-(2-ethylhexyl) phthalate in rats of different selenium status.
- Erkekoglu, Pinar
- Giray, Belma Kocer
- Kizilgun, Murat
- Hininger Favier, Isabelle
- Rachidi, Walid
- Roussel, Anne-Marie
- Favier, Alain
- Hincal, Filiz
DOIAbstract
International audienceThis study was designed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on thyroid hormone levels and oxidant/antioxidant parameters in the rat and to evaluate the effects of selenium status. Selenium deficiency was produced by feeding 3-week-old Sprague-Dawley rats with <0.05 mg selenium/kg body weight for 5 weeks, and the supplementation group received a diet of 1 mg selenium/kg body weight. DEHP-treated groups received the compound at a dose of 1000 mg/kg by gavage during the last 10 days of the feeding period. Levels of thyroid hormone levels as well as selenoenzyme (glutathione peroxidase 1, thioredoxin reductase), catalase, and superoxide dismutase (SOD) activity and thiobarbituric acid reactive ...
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