Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are currently incurable due to primary or secondary resistance to glucocorticoid-based therapies. Here we employed an integrated approach to selectively kill T-ALL cells by increasing mitochondrial reactive oxygen species (ROS) using NS1619, a benzimidazolone that activates the K+ (BK) channel, and dehydroepiandrosterone (DHEA), which blunts ROS scavenging through inhibition of the pentose phosphate pathway. These compounds selectively killed T-ALL cell lines, patient-derived xenografts and primary cells from patients with refractory T-ALL, but did not kill normal human thymocytes. T-ALL cells treated with NS1619 and DHEA showed activation of the ROS-respons...
Purpose: The intracellular redox environment of acute myeloid leukemia (AML) cells is often highly o...
AbstractDespite progress in the treatment of acute lymphoblastic leukemia (ALL), T-cell ALL (T-ALL) ...
Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecu...
Abstract Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are cur...
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a rare neoplasia accounting for 15% of ALL....
mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and is associated with ...
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 tha...
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 tha...
To overcome poor treatment response of pediatric high-risk acute lymphoblastic leukemia (ALL), novel...
We investigated and modelled the mesenchymal stromal cell (MSC) niche in adult acute lymphoblastic l...
peer reviewedT cells are a central component of defenses against pathogens and tumors. Their effecto...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy. Despite recent ...
International audienceAcute myeloid leukemia (AML) is characterized by the accumulation of undiffere...
Glucocorticoids are exploited for the treatment of hematological malignancies due to their ability t...
Background Redox stress is a hallmark of the rewired metabolic phenotype of cancer. The underlyin...
Purpose: The intracellular redox environment of acute myeloid leukemia (AML) cells is often highly o...
AbstractDespite progress in the treatment of acute lymphoblastic leukemia (ALL), T-cell ALL (T-ALL) ...
Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecu...
Abstract Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are cur...
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a rare neoplasia accounting for 15% of ALL....
mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and is associated with ...
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 tha...
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 tha...
To overcome poor treatment response of pediatric high-risk acute lymphoblastic leukemia (ALL), novel...
We investigated and modelled the mesenchymal stromal cell (MSC) niche in adult acute lymphoblastic l...
peer reviewedT cells are a central component of defenses against pathogens and tumors. Their effecto...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy. Despite recent ...
International audienceAcute myeloid leukemia (AML) is characterized by the accumulation of undiffere...
Glucocorticoids are exploited for the treatment of hematological malignancies due to their ability t...
Background Redox stress is a hallmark of the rewired metabolic phenotype of cancer. The underlyin...
Purpose: The intracellular redox environment of acute myeloid leukemia (AML) cells is often highly o...
AbstractDespite progress in the treatment of acute lymphoblastic leukemia (ALL), T-cell ALL (T-ALL) ...
Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecu...