Bromophycoic Acids: Bioactive natural products from a Fijian red alga Callophycus sp.
- Teasdale, M.E.
- Shearer, T.L.
- Engel, S.
- Alexander, T.S.
- Fairchild, C.R.
- Prudhomme, J.
- Torres, M.
- Le Roch, K.
- Aalbersberg, William G.L.
- Hay, M.E.
- Kubanek, J.
Publication date
January 2012
DOI Publisher
American Chemical Society (ACS) ISSN
0022-3263 Citation count (estimate)
12Abstract
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A"12E (1"125) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF
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