Factor V deficiency in pregnancy complicated by Rh immunization and placenta previa. A case report and review of the literature

Labor and postpartum are described as possible hemorrhagic risk factors in women with factor V deficiency. The overall prevalence of hemorrphagic complications is reported to be 78%. Prophylactic transfusions of blood and plasma can reduce these complications. We describe the management in a particular case in which severe factor V deficiency in pregnancy wasassociated with a hemorrhagic condition as vaginal bleeding due to placenta previa, anemia and Rh immunization. Satisfactory hemostasis was achieved by infusion of 15-20 mVkg body weight of fresh frozen plasma before amniocentesis, condocentesis, cesarean section and during puerperium. Intravascular direct fetal transfusion was done to correct fetal anemia. Good maternal and neonatal outcomes were observed Adequate amounts of fresh frozen plasma administered before amniocentesis, conrdocentesis, and during caesarean section and puerperium were found satisfactory as prophylaxis for severe maternal hemorragia in a woman with vaginal bleeding due to placenta previa