Add to ORKGThe pharmacokinetic profile of caffeine was studied in 15 premature infants. Five infants received a single intravenous dose of 10 mg/kg of caffeine citrate 100% at birth and on the 15th day of life. Ten neonates were studied during daily therapy with caffeine for prophylaxis of idiopathic apnea. The time course of plasma and urinary concentrations of caffeine and theophylline shows that caffeine is transformed to theophylline at birth, while total urinary xanthines decrease significantly (p less than 0.001) 72 h after the loading dose given on the 15th day of life. During the whole period of treatment, the decrease in total urinary xanthines and the constant urinary percentage elimination of theophylline are due to further metabolism of th...
Considerable uncertainty persists regarding the efficacy and safety of methylxanthines (caffeine, th...
Purpose : Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug m...
Caffeine is one of the most commonly used therapies in Neonatology, with different indications such ...
The pharmacokinetic profile of caffeine was studied in 15 premature infants. Five infants received a...
The efficacy of orally administered caffeine as a 1% （w/v） ethanolic solution （10%v/v） at a loading ...
We describe the influence of developmental, demographic and clinical determinants on caffeine pharma...
The objective of this study was to develop a population model of the pharmacokinetics (PK) of caffei...
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % o...
Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of prematurity. Fa...
The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evalua...
The population pharmacokinetics (PK) and pharmacodynamics (PD) of theophylline were investigated in ...
Due to the importance of prevention of apnea of prematurity in the very preterm infants and the side...
Background This study sought to assess the pharmacokinetic and pharmacodynamic relationships of caff...
SUMMARY The developmental changes in caffeine elimination were studied in 7 infants aged between 21 ...
The incidence of preterm birth is increasing, leading to a growing population with potential long-te...
Considerable uncertainty persists regarding the efficacy and safety of methylxanthines (caffeine, th...
Purpose : Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug m...
Caffeine is one of the most commonly used therapies in Neonatology, with different indications such ...
The pharmacokinetic profile of caffeine was studied in 15 premature infants. Five infants received a...
The efficacy of orally administered caffeine as a 1% （w/v） ethanolic solution （10%v/v） at a loading ...
We describe the influence of developmental, demographic and clinical determinants on caffeine pharma...
The objective of this study was to develop a population model of the pharmacokinetics (PK) of caffei...
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % o...
Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of prematurity. Fa...
The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evalua...
The population pharmacokinetics (PK) and pharmacodynamics (PD) of theophylline were investigated in ...
Due to the importance of prevention of apnea of prematurity in the very preterm infants and the side...
Background This study sought to assess the pharmacokinetic and pharmacodynamic relationships of caff...
SUMMARY The developmental changes in caffeine elimination were studied in 7 infants aged between 21 ...
The incidence of preterm birth is increasing, leading to a growing population with potential long-te...
Considerable uncertainty persists regarding the efficacy and safety of methylxanthines (caffeine, th...
Purpose : Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug m...
Caffeine is one of the most commonly used therapies in Neonatology, with different indications such ...