Intensity-modulated radiotherapy with simultaneous integrated boost to dominant intraprostatic lesion: preliminary report on toxicity
- Ippolito, Edy
- Mantini, Giovanna (ORCID:0000-0001-5303-4499)
- Morganti, Alessio Giuseppe
- Mazzeo, Ercole
- Padula, Gda
- Digesu', Cinzia
- Cilla, Savino
- Frascino, Vincenzo
- Luzi, Stefano (ORCID:0000-0003-4076-6089)
- Massaccesi, Mariangela
- Macchia, Gabriella
- Deodato, Francesco (ORCID:0000-0003-1276-5070)
- Mattiucci, Gian Carlo (ORCID:0000-0001-6500-0413)
- Piermattei, Angelo (ORCID:0000-0002-6835-1179)
- Cellini, Numa
DOIAbstract
OBJECTIVES: To evaluate the feasibility of intensity-modulated radiotherapy with simultaneous integrated boost to the dominant intraprostatic lesion for definitive treatment of prostate cancer. MATERIALS AND METHODS: Patients were deemed eligible for the study if they had histologically proven stage cT2-T3 N0M0 prostate adenocarcinoma. In addition <20% risk of lymph nodal involvement according to Roach formula, was required for enrollment. Patients were treated with intensity-modulated radiotherapy with simultaneous integrated boost technique to the dominant intraprostatic lesion defined by magnetic resonance imaging. The prescribed dose to the prostate and seminal vesicles was 72 Gy (1.8 Gy per fraction). The dose delivered to the intra...
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