Add to ORKGIntroduction: In early stages of Alzheimer’s disease, that precede plaque formation and neuronal death, cognitive deficits are likely the result of synaptic function impairment. The key initiating pathogenic event is the accumulation of neurotoxic aggregates of amyloid β-peptide (Aβ) in hippocampus and cortex. We previously demonstrated that the redox state of methionine in position 35 (Met35) plays a critical role in Aβ toxicity. Objective: To determine whether oxidation of Met35 also influences Aβ synaptotoxicity we investigated the effects of 20-min lasting perfusion with 200 nM AβWT and its oxidized analogues (AβMet35(O), AβMet35(O2)) on synaptic transmission and plasticity, and on synaptophysin (Syn) expression. Methods: We performed...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Beta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor p...
Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunctio...
Perisynaptic accumulations of amyloid \u3b2-protein (A\u3b2) play a critical role in the synaptic dy...
Aggregation of the amyloid-β (Aβ) peptide into amyloid plaques is a characteristic feature of Alzhei...
An important component of the pathologic process underlying Alzheimer’s disease (AD) is oxidative st...
The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzh...
It is generally believed that the amyloid-β peptide plays a central causative role in the pathogenes...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Amyloid beta-peptide (1–42) [Ah(1–42)] has been proposed to play a central role in the pathogenesis ...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
AbstractRecent theoretical calculations predicted that Gly33 of one molecule of amyloid β-peptide (1...
AbstractAmyloid-β peptide (Aβ), the major constituent of senile plaques in the Alzheimer’s disease (...
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Beta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor p...
Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunctio...
Perisynaptic accumulations of amyloid \u3b2-protein (A\u3b2) play a critical role in the synaptic dy...
Aggregation of the amyloid-β (Aβ) peptide into amyloid plaques is a characteristic feature of Alzhei...
An important component of the pathologic process underlying Alzheimer’s disease (AD) is oxidative st...
The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzh...
It is generally believed that the amyloid-β peptide plays a central causative role in the pathogenes...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
Amyloid beta-peptide (1–42) [Ah(1–42)] has been proposed to play a central role in the pathogenesis ...
It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of d...
AbstractRecent theoretical calculations predicted that Gly33 of one molecule of amyloid β-peptide (1...
AbstractAmyloid-β peptide (Aβ), the major constituent of senile plaques in the Alzheimer’s disease (...
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Amyloid β-peptide [Aβ(1-42)] is central to the pathogenesis of Alzheimer's disease (AD), and the AD ...
Beta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor p...