This paper discusses the potential therapeutic effect of α7-nAChR antagonists for NSCLC (non small cell lung cancer) and MPM (malignant pleural mesothelioma). This therapeutic approach is based on the experimental observations that: (a) functional α7-nAChR are expressed in NSCLC and MPM cells, (b) the activation of these receptors by agonists, namely nicotine, induces cell proliferation and inhibits apoptosis, whereas antagonists have a pro-apoptotic effect. Among competitive α7-nAChR antagonists, d-tubocurarine and -cobratoxin (α-CbT), from the snake venom of Naja, emerged as possible drug candidates. However, some aspects of the samples must be particularly taken into account, such as the particular nature of the sample. Thus, when using ...
Cancer is a disease with poor response rates on available treatments. Problems with resistance and i...
Objective: Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in developing count...
Nicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors lo...
Human malignant pleural mesothelioma (MPM) is a dreadful disease and there is still no standard ther...
Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nACh...
Nicotinic acetylcholine receptors (nAChR) are expressed on normal bronchial epithelial and nonsmall ...
Nicotinic acetylcholine receptors (nAChR) are expressed on bronchial epithelial and non-small cell l...
International audienceThe nicotinic acetylcholine receptor (nAChR) represents the prototype of ligan...
While cancer chemotherapy continues to significantly contribute to the number of cancer survivors, e...
OBJECTIVES: Lung cancer is the most common cause of cancer death in the world. Cigarette smoking...
Lung cancers express the cholinergic autocrine loop, which facilitates the progression of cancer cel...
Nicotinic acetylcholine receptors (nAChRs) are expressed in normal bronchial epithelial and in non-s...
Monepantel (MPL) is a novel anthelmintic drug from a new class of synthetic chemicals known as Amino...
The alkylpyridinium polymer APS8, a potent antagonist of α7 nicotinic acetylcholine receptors ...
The incidence of human malignant pleural mesothelioma (hMPM) is still increasing worldwide. hMPM pro...
Cancer is a disease with poor response rates on available treatments. Problems with resistance and i...
Objective: Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in developing count...
Nicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors lo...
Human malignant pleural mesothelioma (MPM) is a dreadful disease and there is still no standard ther...
Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nACh...
Nicotinic acetylcholine receptors (nAChR) are expressed on normal bronchial epithelial and nonsmall ...
Nicotinic acetylcholine receptors (nAChR) are expressed on bronchial epithelial and non-small cell l...
International audienceThe nicotinic acetylcholine receptor (nAChR) represents the prototype of ligan...
While cancer chemotherapy continues to significantly contribute to the number of cancer survivors, e...
OBJECTIVES: Lung cancer is the most common cause of cancer death in the world. Cigarette smoking...
Lung cancers express the cholinergic autocrine loop, which facilitates the progression of cancer cel...
Nicotinic acetylcholine receptors (nAChRs) are expressed in normal bronchial epithelial and in non-s...
Monepantel (MPL) is a novel anthelmintic drug from a new class of synthetic chemicals known as Amino...
The alkylpyridinium polymer APS8, a potent antagonist of α7 nicotinic acetylcholine receptors ...
The incidence of human malignant pleural mesothelioma (hMPM) is still increasing worldwide. hMPM pro...
Cancer is a disease with poor response rates on available treatments. Problems with resistance and i...
Objective: Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in developing count...
Nicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors lo...