GnRH receptors (GnRH-R) have been found in various malignancies, including prostate cancer (PCa). They mediate the direct antitumor effects of GnRH analogs. Nevertheless, few reports concern drug-induced modulation of GnRH-R levels. In this study, we investigated GnRH-R expression in androgen-sensitive (LNCaP) and -insensitive (PC-3) PCa cells treated for 4 and 6 days with a GnRH agonist (Leuprorelin acetate, LA, 10(-11) or 10(-6) M), Dihydrotestosterone (DHT, 10(-9) M), Cyproterone acetate (CA, 10(-7) M), and Epidermal growth factor (EGF, 10 ng/ml), either alone or combined. The RT-PCR analysis showed no variation in GnRH-R mRNA levels of both treated LNCaP and PC-3 cells. On the contrary, immunoblotting indicated that in LNCaP and PC-3 ce...
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is we...
The mechanisms by which a GnRH analogue, leuprorelin acetate (LA), antagonizes the mitogenic effect...
GnRH II has important functional effects in steroid hormone-dependent tumours. Here we investigated ...
GnRH receptors (GnRH-R) have been found in various malignancies, including prostate cancer (PCa). Th...
Gonadotropin-releasing hormone analogue (GnRHa) therapy is an established method of androgen withdra...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the ext...
Background and Aims: Human metastatic prostate cancer cell growth can be inhibited by GnRH analogs ...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
Pituitary Gonadotropin-Releasing Hormone receptors (GnRH-R) mediate the activity of the hypothalamic...
Contradictory data have been reported regarding the effect of GnRH agonists and antagonists on cell ...
Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hor...
Contradictory data have been reported regarding the effect of GnRH agonists and antag-onists on cell...
BACKGROUND. GnRH analogs have antiproliferative and/or apoptotic effects on prostate cancer cells. A...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is we...
The mechanisms by which a GnRH analogue, leuprorelin acetate (LA), antagonizes the mitogenic effect...
GnRH II has important functional effects in steroid hormone-dependent tumours. Here we investigated ...
GnRH receptors (GnRH-R) have been found in various malignancies, including prostate cancer (PCa). Th...
Gonadotropin-releasing hormone analogue (GnRHa) therapy is an established method of androgen withdra...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the ext...
Background and Aims: Human metastatic prostate cancer cell growth can be inhibited by GnRH analogs ...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
Pituitary Gonadotropin-Releasing Hormone receptors (GnRH-R) mediate the activity of the hypothalamic...
Contradictory data have been reported regarding the effect of GnRH agonists and antagonists on cell ...
Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hor...
Contradictory data have been reported regarding the effect of GnRH agonists and antag-onists on cell...
BACKGROUND. GnRH analogs have antiproliferative and/or apoptotic effects on prostate cancer cells. A...
We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprore...
The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is we...
The mechanisms by which a GnRH analogue, leuprorelin acetate (LA), antagonizes the mitogenic effect...
GnRH II has important functional effects in steroid hormone-dependent tumours. Here we investigated ...