Oxidative stress seems to play a major role in the pathogenesis of neurodegeneration. In Parkinson's disease (PD) patients, the dopaminergic neurons are subjected to oxidative stress resulting from reduced levels of antioxidant defenses such as glutathione and high amount of intracellular iron. Levodopa (LD) is widely used for the symptomatic treatment of PD, but its role in oxidative damage control is still unclear. The aim of this study was to analyze the presence of DNA damage in peripheral blood lymphocytes (PBL) of PD patients, during a washout and a controlled LD dosage and to evaluate the oxidative damage fluctuation after LD intake. The standard and the Fpg-modified version of Comet assay were applied in analyzing DNA damage in PBL ...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...
Levodopa (L-dopa) is the most widely used agent for the symptomatic relief of Parkinson's disease. T...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...
The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum ...
Oxidative stress, resulting from the imbalance between reactive oxygen species (ROS) formation and a...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by decr...
""Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by de...
The relationship between two pathological hallmarks of Parkinson’s disease (PD), i.e. selective loss...
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective...
Oxidative stress plays a central role in the pathogenesis of Parkinson's disease (PD). L-DOPA, the g...
Levodopa is the “gold standard ” for the symptomatic treatment of Parkinson’s disease (PD). There is...
AIMS: There is increasing evidence of biochemical alterations in peripheral blood lymphocytes of Par...
Parkinson’s disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and ...
The objective of this workshop was to review and discuss the debate on neurotoxicity of levodopa in ...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...
Levodopa (L-dopa) is the most widely used agent for the symptomatic relief of Parkinson's disease. T...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...
The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum ...
Oxidative stress, resulting from the imbalance between reactive oxygen species (ROS) formation and a...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by decr...
""Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by de...
The relationship between two pathological hallmarks of Parkinson’s disease (PD), i.e. selective loss...
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and neuroprotective...
Oxidative stress plays a central role in the pathogenesis of Parkinson's disease (PD). L-DOPA, the g...
Levodopa is the “gold standard ” for the symptomatic treatment of Parkinson’s disease (PD). There is...
AIMS: There is increasing evidence of biochemical alterations in peripheral blood lymphocytes of Par...
Parkinson’s disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and ...
The objective of this workshop was to review and discuss the debate on neurotoxicity of levodopa in ...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...
Levodopa (L-dopa) is the most widely used agent for the symptomatic relief of Parkinson's disease. T...
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidati...