Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of carcinogens and anticancer drugs, known also to interact with kinase complexes during oxidative or chemical stress-induced apoptosis. We were interested whether their polymorphic variants may account for differences in outcome of patients with acute myeloid leukemia (AML) following chemotherapy. We studied the prognostic role of polymorphisms in three GST genes (GSTP1/M1/T1) in a large patient cohort of the German Austrian Acute Myeloid Leukemia Study Group, treated according to prospective multicenter clinical trials (AML HD98A: 254 patients; AML HD98-B: 100 patients), with a median follow-up of 46 months. Looking at short-term adverse drug ...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Introduction: Associations between polymorphisms for genes encoding enzymes involved in biotransform...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Introduction: Associations between polymorphisms for genes encoding enzymes involved in biotransform...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophile...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmenta...
Introduction: Associations between polymorphisms for genes encoding enzymes involved in biotransform...