Evaluating genetic risk for prostate cancer among Japanese and Latinos
- Cheng, I.
- Chen, G. K.
- Nakagawa, H.
- He, J.
- Wan, P.
- Laurie, C. C.
- Shen, J.
- Sheng, X.
- Pooler, L. C.
- Crenshaw, A. T.
- Mirel, D. B.
- Takahashi, A.
- Kubo, M.
- Nakamura, Y.
- Al Olama, A. A.
- Benlloch, Sara
- Donovan, Jenny
- Guy, M.
- Hamdy, F. C.
- Kote-Jarai, Z.
- Neal, D. E.
- Wilkens, L. R.
- Monroe, K. R.
- Stram, D. O.
- Muir, Kenneth
- Eeles, R. A.
- Easton, Douglas F.
- Kolonel, L. N.
- Henderson, B. E.
- Le Marchand, L.
- Haiman, C. A.
DOIAbstract
Background There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods Our first stage GWAS of prostate cancer included Japanese (cases/controls=1,033/1,042) and Latino (cases/controls=1,043/1,057) from the Multiethnic Cohort. Significant associations from stage 1 (P < 1.0×10−4) were examined in silico in GWAS of prostate cancer (stage 2) in Japanese (cases/controls=1,583/3,386) and Europeans (cases/controls=1,854/1,894). Results No ...
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