Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, including Huntington disease (HD). The CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring) chaperonin complex can inhibit aggregation and cellular toxicity induced by expanded repeat Huntingtin (mHtt) fragments. The substrate-binding apical domain of CCT/TRiC subunit CCT1, ApiCCT1, is sufficient to inhibit aggregation of expanded repeat mHtt fragments in vitro, providing therapeutic promise for HD. However, a key hurdle in considering ApiCCT1 as a potential treatment is in delivery. Because ApiCCT1 has a region of similarity to the HIV Tat protein cell-transduction domain, we tested whether recombinant ApiCCT1 (ApiCCT1r) protein could enter cells fo...
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mech...
Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expa...
Despite the fact that the gene responsible for Huntington's disease (HD) is known, we still do not u...
Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, inclu...
Huntington’s disease (HD) is a genetic neurodegenerative disease caused by a polyglutamine (PolyQ) r...
Huntington disease (HD) is a progressive neurodegenerative disease caused by an expansion of a polyg...
International audienceBackground:In Huntington’s disease (HD), the ratio between normal and mutant H...
Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mecha...
Polyglutamine (polyQ)-expansion proteins cause neurodegenerative disorders including Huntington's di...
Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a trinu...
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion...
Summary: Huntington disease (HD) is a devastating neurodegenerative disorder characterized by aggreg...
Most neurodegenerative diseases are linked to aberrant accumulation of aggregation-prone proteins. A...
Mechanisms to reduce the cellular levels of mutant huntingtin (mHtt) provide promising strategies fo...
Huntington's disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the...
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mech...
Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expa...
Despite the fact that the gene responsible for Huntington's disease (HD) is known, we still do not u...
Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, inclu...
Huntington’s disease (HD) is a genetic neurodegenerative disease caused by a polyglutamine (PolyQ) r...
Huntington disease (HD) is a progressive neurodegenerative disease caused by an expansion of a polyg...
International audienceBackground:In Huntington’s disease (HD), the ratio between normal and mutant H...
Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mecha...
Polyglutamine (polyQ)-expansion proteins cause neurodegenerative disorders including Huntington's di...
Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a trinu...
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion...
Summary: Huntington disease (HD) is a devastating neurodegenerative disorder characterized by aggreg...
Most neurodegenerative diseases are linked to aberrant accumulation of aggregation-prone proteins. A...
Mechanisms to reduce the cellular levels of mutant huntingtin (mHtt) provide promising strategies fo...
Huntington's disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the...
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mech...
Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expa...
Despite the fact that the gene responsible for Huntington's disease (HD) is known, we still do not u...