The article aims to present a systemic and comparative framework to study adaptation to climate change in agricultural systems. Mediterranean viticulture, projected to experience significant and rapid changes in climate, is used as a case study. We apply an international socio-ecological approach focusing on viticulture in Roussillon (France) and McLaren Vale (Australia). Mixed-methods, including analysis of meteorological data, semi-structured interviews and field observations, guide an analysis of the exposure, sensitivity and adaptation of the two viticultural systems to climate change. We found that the exposure to climate change is likely to become more acute in the two regions by 2060, and that the sensitivity and adaptive capacity of...