This paper presents HyFlex, a software framework for the development of cross-domain search methodologies. The framework features a common software interface for dealing with different combinatorial optimisation problems and provides the algorithm components that are problem specific. In this way, the algorithm designer does not require a detailed knowledge of the problem domains and thus can concentrate his/her efforts on designing adaptive general-purpose optimisation algorithms. Six hard combinatorial problems are fully implemented: maximum satisfiability, one dimensional bin packing, permutation flow shop, personnel scheduling, traveling salesman and vehicle routing. Each domain contains a varied set of instances, including real-world i...