Chemical probes for the recognition of cannabinoid receptors in native systems.
- Martín-Couce, Lidia
- Martín-Fontecha, Mar
- Palomares, Oscar
- Mestre, Leyre
- Cordomí, Arnau
- Hernangomez Herrero, Miriam
- Palma, Sara
- Pardo, Leonardo
- Guaza, Carmen
- López-Rodríguez, María L
- Ortega-Gutiérrez, Silvia
Publication date
July 2012
DOI Publisher
Wiley ISSN
1433-7851 Citation count (estimate)
13Abstract
Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB(1) and CB(2) cannabinoid receptors (CB(1)R and CB(2)R) enable direct visualization of these receptors in native cellular systems, including neurons, microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system.Journal ArticleResearch Support, Non-U.S. Gov'tFLWINinfo:eu-repo/semantics/publishe
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