Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury.
- Ayata, Cemil Korcan
- Ganal, Stephanie C
- Hockenjos, Birgit
- Willim, Karolina
- Vieira, Rodolfo Paula
- Grimm, Melanie
- Robaye, Bernard
- Boeynaems, Jean-Marie
- Di Virgilio, Francesco
- Pellegatti, Patrizia
- Diefenbach, Andreas
- Idzko, Marco
- Hasselblatt, Peter
Publication date
December 2012
DOI Publisher
Elsevier BV ISSN
0016-5085 Citation count (estimate)
43Abstract
During progression of liver disease, inflammation affects survival of hepatocytes. Endogenous release of adenosine triphosphate (ATP) in the liver activates purinergic P2 receptors (P2R), which regulate inflammatory responses, but little is known about the roles of these processes in the development of acute hepatitis.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
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