Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis

Mader, K. T.
Tetteh, J.
McAuley, W. J.
Lane, M. E.
Hadgraft, J.
Andanson, J. M.
Kazarian, S. G.

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Publication date

October 2010

DOI

10.1111/j.2042-7158.2010.01178.x

Publisher

Wiley

Journal

Journal of Pharmacy and Pharmacology

Abstract

The definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Wiley-Blackwell [Full text of this paper is not available in the UHRA]ATR-FTIR spectroscopic imaging permeation experiments of a model formulation across stratum corneum (SC) were conducted to acquire further understanding of the mechanism of drug permeation. Quantitative iterative target transformation factor analysis (QITTFA) was used for the analysis of the complex and highly overlapping spectroscopic data generated.Peer reviewe

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Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis

Abstract

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Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis

Abstract

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