Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study
- Iwuji, Collins C
- Churchill, Duncan
- Gilleece, Yvonne
- Weiss, Helen A
- Fisher, Martin
DOIAbstract
BACKGROUND Initiating therapy with a low CD4 cell count is associated with a substantially greater risk of disease progression and death than earlier initiation. We examined factors associated with late presentation of HIV using the new European consensus definition (CD4 cell count <350 cells/mm3) and mortality. METHODS Patients newly diagnosed with HIV infection at a UK clinic were recruited from January 1996 to May 2010. Factors associated with late presentation were assessed using logistic regression. Factors associated with mortality rates were analysed using Poisson regression. RESULTS Of the 1536 included in the analysis, 86% were male and 10% were aged 50 years and older. Half the cohort (49%) had a CD4 cell count belo...
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