A potential anti-implantation and spermicidal strategy : Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

Original article can be found at: http://www.informaworld.com/smpp/title~content=t713604167 Copyright Informa. [Full text of this article is not available in the UHRA]We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties. Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487Peer reviewe