“The original publication is available at www.springerlink.com”. Copyright Springer. [Full text of this article is not available in UHRA]To investigate the influence of type and amount of excipient on the preservation of the native structure and the biologic activity of freeze-dried lysozyme and catalasePeer reviewe
Many proteins are able to self-assembly into well-defined supramolecular structures. We have previou...
Enzymes typically have a critical instability, which dominates both formulation and process developm...
Biopharmaceuticals are often stored in a lyophilized form. However, stresses due to both the freezin...
Freeze-drying, or lyophilization, is the most commonly used technique for the preservation of protei...
The effects of freeze-thawing and freeze-drying on catalase, one of globular proteins, were examined...
The broad objective of this study was to gain a better understanding of the effects of formulation a...
Biopharmaceuticals are frequently stored in the frozen state to avoid rapid degradation. Moreover, t...
The long-term stability of a protein formulation requires that the glass transition temperature (T-g...
The number of protein-based pharmaceuticals has rapidly increased in the last decade and their share...
Problem - The primary objective of this dissertation was to elucidate the protective effects and mec...
The broad objective of this study was to gain an improved understanding of the impact of formulation...
Even though freeze-drying is widely used for the preparation of biopharmaceuticals, it causes stress...
peer-reviewedIn recent years, freeze drying of protein preparations above the collapse temperature o...
The mechanisms of stabilization by sugars during freeze drying and storage are still controversial. ...
Freeze-drying of pharmaceuticals, especially large molecules, has become increasingly important in r...
Many proteins are able to self-assembly into well-defined supramolecular structures. We have previou...
Enzymes typically have a critical instability, which dominates both formulation and process developm...
Biopharmaceuticals are often stored in a lyophilized form. However, stresses due to both the freezin...
Freeze-drying, or lyophilization, is the most commonly used technique for the preservation of protei...
The effects of freeze-thawing and freeze-drying on catalase, one of globular proteins, were examined...
The broad objective of this study was to gain a better understanding of the effects of formulation a...
Biopharmaceuticals are frequently stored in the frozen state to avoid rapid degradation. Moreover, t...
The long-term stability of a protein formulation requires that the glass transition temperature (T-g...
The number of protein-based pharmaceuticals has rapidly increased in the last decade and their share...
Problem - The primary objective of this dissertation was to elucidate the protective effects and mec...
The broad objective of this study was to gain an improved understanding of the impact of formulation...
Even though freeze-drying is widely used for the preparation of biopharmaceuticals, it causes stress...
peer-reviewedIn recent years, freeze drying of protein preparations above the collapse temperature o...
The mechanisms of stabilization by sugars during freeze drying and storage are still controversial. ...
Freeze-drying of pharmaceuticals, especially large molecules, has become increasingly important in r...
Many proteins are able to self-assembly into well-defined supramolecular structures. We have previou...
Enzymes typically have a critical instability, which dominates both formulation and process developm...
Biopharmaceuticals are often stored in a lyophilized form. However, stresses due to both the freezin...