Add to ORKGThere is an urgent need for novel therapeutics possessing new modes of action to treat tuberculosis (TB) infections. In this study we report on the synthesis and biological evaluation of a series of pyrido[2,3,4-kI] acridin-6-one alkaloids related to the anti-TB (MIC 0.35 mu M) but cytotoxic (IC(50) 25 mu M). Another analogue (10) was evaluated against a range of singly-drug-resistant strains of Mtb and was found to exhibit no cross-resistance. These results suggest that the pyrido[2,3,4-kI]acridin-6-one skeleton may provide a useful scaffold for future studies directed towards possible anti-TB drugs. (C) 2010 Elsevier Ltd. All rights reserved
Tuberculosis (TB) represents a never-ending challenge toward which research efforts are needed. Drug...
Antimicrobial resistance, the so-called silent pandemic, is pushing industry and academia to find no...
There has been considerable interest in the development of new molecule with antibacterial activitie...
Abstract: Problem statement: Tuberculosis is a leading global mortality factor which has not been ef...
Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resis...
AbstractA small library of compounds are synthesized and evaluated for their in vitro antitubercular...
Tuberculosis is the number one killer of infectious diseases caused by a single microbe, namely Myco...
The synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer re...
Marine compounds with pyridoacridine skeletons are known to exhibit interesting antitumor activities...
Tuberculosis has been one of the most commonly encountered infectious diseases of humans throughout ...
AbstractNatural products are increasingly being considered “critical and important” in drug discover...
This diploma thesis is devoted to antituberculosis drugs research. A very briefly depicts of genus M...
Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTM...
This thesis reports the synthesis and biological evaluation of novel molecules intended for the trea...
Abstract Tuberculosis (TB) is a major global health issue with a high mortality rate, particularly d...
Tuberculosis (TB) represents a never-ending challenge toward which research efforts are needed. Drug...
Antimicrobial resistance, the so-called silent pandemic, is pushing industry and academia to find no...
There has been considerable interest in the development of new molecule with antibacterial activitie...
Abstract: Problem statement: Tuberculosis is a leading global mortality factor which has not been ef...
Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resis...
AbstractA small library of compounds are synthesized and evaluated for their in vitro antitubercular...
Tuberculosis is the number one killer of infectious diseases caused by a single microbe, namely Myco...
The synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer re...
Marine compounds with pyridoacridine skeletons are known to exhibit interesting antitumor activities...
Tuberculosis has been one of the most commonly encountered infectious diseases of humans throughout ...
AbstractNatural products are increasingly being considered “critical and important” in drug discover...
This diploma thesis is devoted to antituberculosis drugs research. A very briefly depicts of genus M...
Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTM...
This thesis reports the synthesis and biological evaluation of novel molecules intended for the trea...
Abstract Tuberculosis (TB) is a major global health issue with a high mortality rate, particularly d...
Tuberculosis (TB) represents a never-ending challenge toward which research efforts are needed. Drug...
Antimicrobial resistance, the so-called silent pandemic, is pushing industry and academia to find no...
There has been considerable interest in the development of new molecule with antibacterial activitie...