The most active metabolite of vitamin D, calcitriol, is growth inhibitory for various tumor types in vitro and in vivo and inhibits the growth of endothelial cells freshly isolated from tumors tumor-derived endothelial cells (TDEC). We compared the effects of calcitriol on Matrigel-derived endothelial cells (MDEC) and TDEC isolated from Matrigel plugs and squamous cell carcinoma tumors, respectively. TDEC and MDEC expressed vitamin D receptor (VDR) and responded to calcitriol by increasing VDR protein expression. Although no mutations were found in VDR from either cell type, Scatchard plot analysis revealed a higher ligand-binding affinity in TDEC (K-d,K- 0.26 nmol/L) than MDEC (K-d, 0.65 nmol/L). The VDR signaling axis in both cells was in...
Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and h...
As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxych...
Environment may influence the development and prevention of cancer. Calcitriol has been associated w...
Calcitriol (1,25-dihydroxycholecalciferol), the active form of Vitamin D, is anti-proliferative in t...
Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many...
Calcitriol (1,25 dihydroxycholecalciferol) has significant anti-tumor activity in vitro and in vivo ...
The vitamin D receptor is expressed in most tissues of the body – and the cancers that arise from th...
The anticancer actions of vitamin D and its hormonally active form, calcitriol, have been extensivel...
This study was supported by the National Science Center granted on the basis of the decision number ...
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the acti...
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the acti...
Resumen del trabajo presentado al 41 Congreso de la Sociedad Española de Bioquímica y Biología Molec...
Increasing lines of evidence indicate that the biologically active form of vitamin D, calcitriol (1,...
Calcitriol (1,25-dihydroxycholecalciferol), the most active form of vitamin D, has selective anti-pr...
Calcitriol (1 alpha, 25-dihydroxy vitamin D3, 1α,25-(OH)2D3), the most active metabolite of vitamin ...
Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and h...
As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxych...
Environment may influence the development and prevention of cancer. Calcitriol has been associated w...
Calcitriol (1,25-dihydroxycholecalciferol), the active form of Vitamin D, is anti-proliferative in t...
Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many...
Calcitriol (1,25 dihydroxycholecalciferol) has significant anti-tumor activity in vitro and in vivo ...
The vitamin D receptor is expressed in most tissues of the body – and the cancers that arise from th...
The anticancer actions of vitamin D and its hormonally active form, calcitriol, have been extensivel...
This study was supported by the National Science Center granted on the basis of the decision number ...
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the acti...
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the acti...
Resumen del trabajo presentado al 41 Congreso de la Sociedad Española de Bioquímica y Biología Molec...
Increasing lines of evidence indicate that the biologically active form of vitamin D, calcitriol (1,...
Calcitriol (1,25-dihydroxycholecalciferol), the most active form of vitamin D, has selective anti-pr...
Calcitriol (1 alpha, 25-dihydroxy vitamin D3, 1α,25-(OH)2D3), the most active metabolite of vitamin ...
Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and h...
As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxych...
Environment may influence the development and prevention of cancer. Calcitriol has been associated w...