Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains
- Lord, C. J.
- Bohlander, S. K.
- Hopes, E. A.
- Montague, C. T.
- Hill, N. J.
- Prins, J.-B.
- Peterson, L. B.
- Wicker, L. S.
- Todd, J. A.
- Denny, P.
Publication date
September 1995
DOI Publisher
Springer Science and Business Media LLCAbstract
Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM
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