We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated. These muscles revealed new functions for IAPs not required for viability: Focal Adhesion Kinase (FAK), RSU1, tensin and vinculin. Genetic interactions demonstrated a balance between positive and negative activities, with vinculin and tensin positively regulating adhesion, while FAK inhibits elevation of integrin activity by tensin, and RSU1 keeps PINCH activity in check. The molecular composition of myofibril termini resolves into 4 distinct layers, one of which is built by a mechanotransduction cascade: vinculin facilitates mechanical opening of filamin, which works with the...
The somatic musculature of Drosophila is analogous to vertebrate skeletal muscles and is generated b...
Cell-extracellular-matrix adhesion is mediated by cell receptors, mainly integrins and transmembrane...
AbstractThe Drosophila αPS2βPS integrin is required for diverse development events, including muscle...
The ability to adhere to the extracellular matrix (ECM) is critical for numerous cell types and tiss...
Cells in an organism are subjected to numerous sources of external and internal forces, and are able...
<div><p>A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary...
Cells need to sense their environment to ensure accurate targeting to specific destinations. This oc...
Integrins are essential mediators of cell-ECM adhesion and they are, therefore, important to animal ...
The stereotyped striation of myofibrils is a conserved feature of muscle organization that is critic...
Background: Higher animals generate an elaborate muscle-tendon network to perform their movements. T...
SummaryCytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; howeve...
<div><p>Tendons are fibrous connective tissue which connect muscles to the skeletal elements thus ac...
Cytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; however, the ...
Cell-extracellular-matrix adhesion is mediated by cell receptors, mainly integrins and transmembrane...
Tendons are fibrous connective tissue which connect muscles to the skeletal elements thus acting as ...
The somatic musculature of Drosophila is analogous to vertebrate skeletal muscles and is generated b...
Cell-extracellular-matrix adhesion is mediated by cell receptors, mainly integrins and transmembrane...
AbstractThe Drosophila αPS2βPS integrin is required for diverse development events, including muscle...
The ability to adhere to the extracellular matrix (ECM) is critical for numerous cell types and tiss...
Cells in an organism are subjected to numerous sources of external and internal forces, and are able...
<div><p>A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary...
Cells need to sense their environment to ensure accurate targeting to specific destinations. This oc...
Integrins are essential mediators of cell-ECM adhesion and they are, therefore, important to animal ...
The stereotyped striation of myofibrils is a conserved feature of muscle organization that is critic...
Background: Higher animals generate an elaborate muscle-tendon network to perform their movements. T...
SummaryCytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; howeve...
<div><p>Tendons are fibrous connective tissue which connect muscles to the skeletal elements thus ac...
Cytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; however, the ...
Cell-extracellular-matrix adhesion is mediated by cell receptors, mainly integrins and transmembrane...
Tendons are fibrous connective tissue which connect muscles to the skeletal elements thus acting as ...
The somatic musculature of Drosophila is analogous to vertebrate skeletal muscles and is generated b...
Cell-extracellular-matrix adhesion is mediated by cell receptors, mainly integrins and transmembrane...
AbstractThe Drosophila αPS2βPS integrin is required for diverse development events, including muscle...