Extra-cytoplasmic function (ECF) sigma-factors are widespread in bacteria, linking environmental stimuli with changes in gene expression. These transcription factors span several phylogenetically distinct groups and are remarkably diverse in their activation and regulatory mechanisms. Here, we describe the structural and biochemical features of a Mycobacterium tuberculosis ECF factor sigma(J) that suggests that the SnoaL2 domain at the C-terminus can modulate the activity of this initiation factor in the absence of a cognate regulatory anti-sigma factor. M. tu-berculosis sigma(J) can bind promoter DNA in vitro; this interaction is substantially impaired by the removal of the SnoaL2 domain. This finding is consistent with assays to evaluate ...
Dostalova H, Busche T, Holatko J, et al. Overlap of Promoter Recognition Specificity of Stress Respo...
Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends...
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma f...
Extra-cytoplasmic function (ECF) sigma-factors are widespread in bacteria, linking environmental sti...
The extracytoplasmic factor (ECF) sigma factor sigma(E) is one of the most studied sigma factors of ...
The association of a factors with the RNA polymerase dictates the expression profile of a bacterial ...
σ factors are transcriptional regulatory proteins that bind to the RNA polymerase and dictate gene e...
The relative levels of different sigma factors dictate the expression profile of a bacterium. Extrac...
Mycobacterium tuberculosis has multiple sigma factors which enable the bacterium to reprogram its tr...
Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in various har...
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate b...
Earlier studies from our laboratory on randomly isolated transcriptional signals of mycobacteria had...
Sigma factors are transcription-regulatory proteins that bind to RNA polymerase and facilitate promo...
The host-pathogen interactions in Mycobacterium tuberculosis infection are significantly influenced ...
Alternative sigma factors regulate the activity of RNA polymerases under specific conditions and are...
Dostalova H, Busche T, Holatko J, et al. Overlap of Promoter Recognition Specificity of Stress Respo...
Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends...
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma f...
Extra-cytoplasmic function (ECF) sigma-factors are widespread in bacteria, linking environmental sti...
The extracytoplasmic factor (ECF) sigma factor sigma(E) is one of the most studied sigma factors of ...
The association of a factors with the RNA polymerase dictates the expression profile of a bacterial ...
σ factors are transcriptional regulatory proteins that bind to the RNA polymerase and dictate gene e...
The relative levels of different sigma factors dictate the expression profile of a bacterium. Extrac...
Mycobacterium tuberculosis has multiple sigma factors which enable the bacterium to reprogram its tr...
Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in various har...
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate b...
Earlier studies from our laboratory on randomly isolated transcriptional signals of mycobacteria had...
Sigma factors are transcription-regulatory proteins that bind to RNA polymerase and facilitate promo...
The host-pathogen interactions in Mycobacterium tuberculosis infection are significantly influenced ...
Alternative sigma factors regulate the activity of RNA polymerases under specific conditions and are...
Dostalova H, Busche T, Holatko J, et al. Overlap of Promoter Recognition Specificity of Stress Respo...
Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends...
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma f...