The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme pool through multiple back-up mechanisms
Significance: Heme is an essential prosthetic group for most life on Earth. It functions in numerous...
<p>H, heme; Hb, hemoglobin; FV, food vacuole; M, mitochondrion; Ap, apicoplast; Gly, glycine; SCoA, ...
Plasmodium falciparum is a parasite that causes severe type of malaria, including cerebral malaria. ...
The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglo...
<div><p>Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host...
The malarial parasite imports an infected host's red blood cell enzymes for heme biosynthesis during...
The malarial parasite manifests unique features of heme metabolism. In the intraerythrocyte stage it...
The malarial parasite manifests unique features of heme metabolism. In the intraerythrocyte stage it...
Malaria is a life-threatening vector borne infectious disease caused by protozoan parasites of the g...
The Apicomplexa phylum groups important human and animal pathogens that cause severe diseases, encom...
The mouse and human malarial parasites, Plasmodium berghei and Plasmodium falciparum, respectively, ...
All eight enzymes required for de novo heme biosynthesis have been predicted from the nuclear genome...
A number of antimalarial drugs interfere with the electron transport chain and heme-related reaction...
Although malaria is a well-studied infectious disease, we are still unable to fight it effectively, ...
The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty m...
Significance: Heme is an essential prosthetic group for most life on Earth. It functions in numerous...
<p>H, heme; Hb, hemoglobin; FV, food vacuole; M, mitochondrion; Ap, apicoplast; Gly, glycine; SCoA, ...
Plasmodium falciparum is a parasite that causes severe type of malaria, including cerebral malaria. ...
The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglo...
<div><p>Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host...
The malarial parasite imports an infected host's red blood cell enzymes for heme biosynthesis during...
The malarial parasite manifests unique features of heme metabolism. In the intraerythrocyte stage it...
The malarial parasite manifests unique features of heme metabolism. In the intraerythrocyte stage it...
Malaria is a life-threatening vector borne infectious disease caused by protozoan parasites of the g...
The Apicomplexa phylum groups important human and animal pathogens that cause severe diseases, encom...
The mouse and human malarial parasites, Plasmodium berghei and Plasmodium falciparum, respectively, ...
All eight enzymes required for de novo heme biosynthesis have been predicted from the nuclear genome...
A number of antimalarial drugs interfere with the electron transport chain and heme-related reaction...
Although malaria is a well-studied infectious disease, we are still unable to fight it effectively, ...
The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty m...
Significance: Heme is an essential prosthetic group for most life on Earth. It functions in numerous...
<p>H, heme; Hb, hemoglobin; FV, food vacuole; M, mitochondrion; Ap, apicoplast; Gly, glycine; SCoA, ...
Plasmodium falciparum is a parasite that causes severe type of malaria, including cerebral malaria. ...
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