Add to ORKGMismatches that arise during replication or genetic recombination or owing to damage to DNA by chemical agents are recognized by mismatch repair systems. The pathway has been characterized in detail in Escherichia coli. Several homologues of the genes encoding the proteins of this pathway have been identified in the yeast Saccharomyces cerevisiae and in human cells. Mutations in the human genes hMSH2, hMLH1, hPMS1 and hPMS2 have been linked to hereditary nonpolyposis colon cancer (HNPCC) and to some sporadic tumours. Mismatch repair also plays an antirecombinogenic role and is implicated in speciation
Mutations in the human mismatch repair protein hMSH2 have been found to cosegregate with hereditary ...
The role of mismatch repair proteins has been well studied in the context of DNA repair following DN...
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products...
Mismatches that arise during replication or genetic recombination or owing to damage to DNA by chemi...
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been link...
Human cells contain several homologs of the bacterial mutL gene required for mismatch repair, includ...
DNA mismatch repair is the process of fixing errors that arise in the genome during DNA replication ...
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH...
Hereditary nonpolyposis colorectal cancer (HNPCC) is attributable to a deficiency of mismatch repair...
Mismatch repair systems correct replication- and recombination-associated mispaired bases and influe...
Deficiencies in mismatch repair have been linked to a common cancer predisposition syndrome in human...
AbstractDNA-mismatch repair removes mismatches from the newly replicated DNA strand. In humans, muta...
Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nat...
Since the discovery of a link between the malfunction of post-replicative mismatch correction and he...
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH...
Mutations in the human mismatch repair protein hMSH2 have been found to cosegregate with hereditary ...
The role of mismatch repair proteins has been well studied in the context of DNA repair following DN...
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products...
Mismatches that arise during replication or genetic recombination or owing to damage to DNA by chemi...
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been link...
Human cells contain several homologs of the bacterial mutL gene required for mismatch repair, includ...
DNA mismatch repair is the process of fixing errors that arise in the genome during DNA replication ...
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH...
Hereditary nonpolyposis colorectal cancer (HNPCC) is attributable to a deficiency of mismatch repair...
Mismatch repair systems correct replication- and recombination-associated mispaired bases and influe...
Deficiencies in mismatch repair have been linked to a common cancer predisposition syndrome in human...
AbstractDNA-mismatch repair removes mismatches from the newly replicated DNA strand. In humans, muta...
Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nat...
Since the discovery of a link between the malfunction of post-replicative mismatch correction and he...
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH...
Mutations in the human mismatch repair protein hMSH2 have been found to cosegregate with hereditary ...
The role of mismatch repair proteins has been well studied in the context of DNA repair following DN...
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products...