The crystal structure of a chimera of Plasmodium falciparum (Pf) and human hypoxanthine guanine phosphoribosyltransferases (HGPRT), which consists of the core of the protein from the human enzyme and the hood region from the Pf enzyme, has been determined as a complex with the product guanosine monophosphate (GMP). The chimera can utilize hypoxanthine, guanine, and xanthine as substrates, similar to the Pf enzyme. It exists as a monomer-dimer mixture in solution, but shifts to a tetramer on addition of phosphoribosyl pyrophosphate (PRPP). The structural studies reveal that the asymmetric unit of the crystal consists of two monomers of the chimeric HGPRT. Surprisingly, the dimer interface of the chimera is the less extensive AC interface of ...
AbstractBackground: Malaria caused by the parasite Plasmodium falciparum is a major public health co...
Human hypoxanthine guanine phosphoribosyltransferase (HGPRT) lacks the ability to phosphoribosylate ...
AbstractHypoxanthine–guanine–xanthine phosphoribosyltransferase (HGXPRT) from Plasmodium falciparum ...
The crystal structure of a chimera of Plasmodium falciparum (Pf) and human hypoxanthine guanine phos...
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxant...
Abstract Background ...
Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan...
ABSTRACT: Malaria is a leading cause of worldwide mortality from infectious disease. Plasmodium falc...
The 6-oxopurine phosphoribosyltransferases (PRTs) are drug targets for the treatment of parasitic di...
The human malaria parasite Plasmodium falciparum is auxotrophic for purines and relies on the purine...
Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyses the synthesis of the purine n...
Background: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. T...
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) from Plasmodium falciparum catalyze...
Enzymatic efficiency and structural discrimination of substrates from nonsubstrate analogues are att...
AbstractGuanine monophosphate (GMP) synthetase is a bifunctional two-domain enzyme. The N-terminal g...
AbstractBackground: Malaria caused by the parasite Plasmodium falciparum is a major public health co...
Human hypoxanthine guanine phosphoribosyltransferase (HGPRT) lacks the ability to phosphoribosylate ...
AbstractHypoxanthine–guanine–xanthine phosphoribosyltransferase (HGXPRT) from Plasmodium falciparum ...
The crystal structure of a chimera of Plasmodium falciparum (Pf) and human hypoxanthine guanine phos...
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the phosphoribosylation of hypoxant...
Abstract Background ...
Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan...
ABSTRACT: Malaria is a leading cause of worldwide mortality from infectious disease. Plasmodium falc...
The 6-oxopurine phosphoribosyltransferases (PRTs) are drug targets for the treatment of parasitic di...
The human malaria parasite Plasmodium falciparum is auxotrophic for purines and relies on the purine...
Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyses the synthesis of the purine n...
Background: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. T...
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) from Plasmodium falciparum catalyze...
Enzymatic efficiency and structural discrimination of substrates from nonsubstrate analogues are att...
AbstractGuanine monophosphate (GMP) synthetase is a bifunctional two-domain enzyme. The N-terminal g...
AbstractBackground: Malaria caused by the parasite Plasmodium falciparum is a major public health co...
Human hypoxanthine guanine phosphoribosyltransferase (HGPRT) lacks the ability to phosphoribosylate ...
AbstractHypoxanthine–guanine–xanthine phosphoribosyltransferase (HGXPRT) from Plasmodium falciparum ...