Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems

The insecticide Thimet 10-G [298-02-2] was tested for mutagenic activity by 4 different genetic systems.It was unable to induce gene mutation in Salmonella,transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister chromatid exchange in human lymphocytes.It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human lymphocytes a decrease in mitotic index and delay in cell cycle.The results indicate that the insecticide is not mutagenic in the 4 test systems used at present