© 2019 Spiliotopoulos et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP4 and USP15 are known to interact with E3 ligases and substrate recruitment factors. No such interactions have been reported for these domains in the paralog USP11, a key regulator of DNA double-strand break repair by homologous recombination. We hypothesized that USP11 domains adjacent to its protease domain harbor unique peptide-binding sites. Here, using a next-generation phage display (NGPD) strategy, combining phage display library screening with next-generation sequencing, we discovered un...
SummaryRecognition of ubiquitin and polyubiquitin chains by ubiquitin-binding domains (UBDs) is vita...
Ubiquitination is a diverse post-translational modification, involved in a plethora of eukaryotic pr...
SummaryConverting lead compounds into drug candidates is a crucial step in drug development, requiri...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
© 2018 Ward et al. Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, in...
12 p.Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
ABSTRACT: The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replicat...
SummaryDeubiquitinating proteases reverse protein ubiquitination and rescue their target proteins fr...
Protein-protein interactions are necessary for virtually all biological processes. There have been t...
Deubiquitinating enzymes play an important role in a plethora of therapeutically relevant processes ...
Defining dynamic protein–protein interactions in the ubiquitin conjugation reaction is a challenging...
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important ...
Ubiquitin-specific protease (USP15) is an important regulator of cellular pathways including transfo...
SummaryRecognition of ubiquitin and polyubiquitin chains by ubiquitin-binding domains (UBDs) is vita...
Ubiquitination is a diverse post-translational modification, involved in a plethora of eukaryotic pr...
SummaryConverting lead compounds into drug candidates is a crucial step in drug development, requiri...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
© 2018 Ward et al. Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, in...
12 p.Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis...
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and T...
ABSTRACT: The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replicat...
SummaryDeubiquitinating proteases reverse protein ubiquitination and rescue their target proteins fr...
Protein-protein interactions are necessary for virtually all biological processes. There have been t...
Deubiquitinating enzymes play an important role in a plethora of therapeutically relevant processes ...
Defining dynamic protein–protein interactions in the ubiquitin conjugation reaction is a challenging...
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important ...
Ubiquitin-specific protease (USP15) is an important regulator of cellular pathways including transfo...
SummaryRecognition of ubiquitin and polyubiquitin chains by ubiquitin-binding domains (UBDs) is vita...
Ubiquitination is a diverse post-translational modification, involved in a plethora of eukaryotic pr...
SummaryConverting lead compounds into drug candidates is a crucial step in drug development, requiri...