Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy
- Rawling, M.J.
- Storr, T.E.
- Bawazir, W.A.
- Cully, S.J.
- Lewis, W.
- Makki, M.S.I.T.
- Strutt, I.R.
- Jones, G.
- Hamza, D.
- Stockman, R.A.
DOIAbstract
A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced
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