Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages
- Rosas-Magallanes, Vania
- Stadthagen-Gomez, Gustavo
- Rauzier, Jean
- Barreiro, Luis B.
- Tailleux, Ludovic
- Boudou, Fr�d�ric
- Griffin, Ruth
- Nigou, J�rome
- Jackson, Mary
- Gicquel, Brigittte
- Neyrolles, Olivier
DOIAbstract
Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells
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