Add to ORKGDietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of a-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression. (c) 2007 Wiley-Liss, Inc.nul
Caloric restriction (CR) can attenuate the general loss of health observed during aging, being one o...
The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the a...
Caloric restriction (CR) is a reduction of total caloric intake without a decrease in micronutrients...
Dietary restriction (DR) is one of the promising environmental interventions known to attenuate agin...
Brain aging is related to the numerous structural and functional changes including decreased synapti...
The objective of this study was to examine the effects of aging and long-term dietary restriction...
Background: A major problem of aging is the disruption of metabolic homeostasis. This is particularl...
Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related ...
Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects ...
Expression profiles of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), apolipoprotein E (Apo...
Neuronal aggregates of misfolded alpha-synuclein protein are found in the brain and periphery of pat...
International audienceCaloric restriction (CR) is the most effective intervention to improve health ...
Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has be...
Dietary restriction (DR, in the form of reduced calorie intake or alternate fasting with overall nor...
Summary. Aging is a complex set of events that involves the whole body. However, disruption of the c...
Caloric restriction (CR) can attenuate the general loss of health observed during aging, being one o...
The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the a...
Caloric restriction (CR) is a reduction of total caloric intake without a decrease in micronutrients...
Dietary restriction (DR) is one of the promising environmental interventions known to attenuate agin...
Brain aging is related to the numerous structural and functional changes including decreased synapti...
The objective of this study was to examine the effects of aging and long-term dietary restriction...
Background: A major problem of aging is the disruption of metabolic homeostasis. This is particularl...
Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related ...
Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects ...
Expression profiles of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), apolipoprotein E (Apo...
Neuronal aggregates of misfolded alpha-synuclein protein are found in the brain and periphery of pat...
International audienceCaloric restriction (CR) is the most effective intervention to improve health ...
Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has be...
Dietary restriction (DR, in the form of reduced calorie intake or alternate fasting with overall nor...
Summary. Aging is a complex set of events that involves the whole body. However, disruption of the c...
Caloric restriction (CR) can attenuate the general loss of health observed during aging, being one o...
The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the a...
Caloric restriction (CR) is a reduction of total caloric intake without a decrease in micronutrients...